Gamete Intrafallopian Transfer (GIFT) is a fertility treatment that offers hope for couples struggling with recurrent miscarriages. While miscarriages are unfortunately common, experiencing multiple losses can be devastating and leave couples feeling helpless. GIFT offers a promising solution for those dealing with recurrent miscarriages, as it allows for the direct transfer of both eggs and sperm into the fallopian tubes, increasing the chances of a successful pregnancy.
In this blog post, we will delve into the details of GIFT, how it works, its success rates, and its potential benefits for couples facing recurrent miscarriages.
What is GIFT?
GIFT is a type of assisted reproductive technology (ART) that combines elements of both in vitro fertilization (IVF) and intrauterine insemination (IUI). It involves retrieving eggs from the woman’s ovaries and combining them with sperm in a laboratory. The resulting mixture is then directly inserted into the fallopian tubes, where fertilization can occur naturally.
The process of GIFT begins with the stimulation of the ovaries using fertility medications to produce multiple eggs. These eggs are then retrieved through a minor surgical procedure known as follicular aspiration. At the same time, a semen sample is collected from the male partner or a donor and prepared in the laboratory.
Next, the eggs and sperm are combined and immediately transferred into the fallopian tubes using a catheter. This process is usually done under light sedation and takes about 30 minutes.
How does GIFT differ from IVF?
The main difference between GIFT and IVF is the location of fertilization. In IVF, fertilization occurs in a laboratory dish, and the resulting embryo is later transferred into the uterus. In GIFT, fertilization takes place inside the woman’s body, in the fallopian tubes.
Additionally, GIFT is a less invasive procedure compared to IVF. It does not require the use of a needle to puncture the egg or the use of a catheter to transfer the embryo into the uterus. This makes GIFT a more natural option for couples who prefer to avoid the laboratory setting.
Success rates of GIFT

Gamete Intrafallopian Transfer: A Hopeful Solution for Recurrent Miscarriages
The success rates of GIFT vary depending on factors such as the age and health of the woman, the quality of the eggs and sperm, and the expertise of the fertility clinic. On average, the success rate of GIFT is around 25%, which is slightly lower than IVF, which has a success rate of 30-35%.
However, for couples dealing with recurrent miscarriages, GIFT can offer a higher chance of success compared to other fertility treatments. This is because fertilization takes place in the fallopian tubes, which are a more natural environment for the embryo to develop.
Benefits of GIFT for recurrent miscarriages
One of the main benefits of GIFT for couples with recurrent miscarriages is the potential to identify and address any underlying issues that may be causing the repeated losses. During the GIFT procedure, the doctor is able to observe the fertilization process in real-time, which can provide valuable information about the quality of the eggs and sperm and any potential obstacles to fertilization.
Additionally, GIFT allows for the direct transfer of both eggs and sperm, which may increase the chances of a successful pregnancy compared to other fertility treatments. It also eliminates the possibility of embryo implantation in the wrong place, which can sometimes happen with IVF.
Is GIFT right for you?
GIFT may be a suitable option for couples who have been diagnosed with unexplained recurrent miscarriages or have had previous failed fertility treatments. It may also be recommended for those with blocked or damaged fallopian tubes, as GIFT bypasses the need for the tubes to be open and functioning.
However, GIFT may not be suitable for everyone. It is not recommended for women with severe endometriosis or a history of pelvic infections, as these conditions can affect the function of the fallopian tubes.
Conclusion
GIFT offers a hopeful solution for couples dealing with recurrent miscarriages. By allowing for the direct transfer of both eggs and sperm into the fallopian tubes, it increases the chances of a successful pregnancy and offers valuable insights into any underlying issues that may be causing the recurring losses. While GIFT may not be suitable for everyone, it provides a more natural and less invasive option for couples struggling to conceive.
In conclusion, GIFT is an important fertility treatment that offers hope for couples dealing with recurrent miscarriages. Its unique approach and potential benefits make it a promising option for those looking to start or expand their family.