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Fertility drugs are commonly used to help women struggling with infertility to ovulate and increase their chances of getting pregnant. These drugs work by stimulating the ovaries to produce more eggs, increasing the chances of fertilization.
However, like any medication, fertility drugs come with potential side effects and risks. One of the most concerning risks associated with fertility drugs is Ovarian Hyperstimulation Syndrome (OHSS). In this blog post, we will delve into what fertility drugs are, how they work, and what you should know about OHSS.
What are Fertility Drugs?
Fertility drugs, also known as ovulation induction medications, are a type of medication used to stimulate the ovaries to produce more eggs. These drugs are commonly used in women who are struggling to conceive due to issues with ovulation.
The most commonly used fertility drugs are Clomiphene citrate (Clomid, Serophene) and Gonadotropins (Follistim, Gonal-F, Menopur). These drugs work by either blocking the effects of estrogen or stimulating the production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). These hormones are crucial for the development and release of an egg from the ovary.
Fertility drugs are usually taken orally or through injections. They can be used alone or in combination with other fertility treatments such as intrauterine insemination (IUI) or in-vitro fertilization (IVF).
How do Fertility Drugs Increase the Risk of OHSS?
OHSS is a potential complication of fertility drugs, especially Gonadotropins. These drugs can cause the ovaries to become enlarged and produce too many follicles, which can lead to the overproduction of hormones.
In a normal menstrual cycle, only one egg is released from the ovary. However, with the use of fertility drugs, multiple eggs can be released, increasing the chances of fertilization. This overstimulation of the ovaries can cause a rapid increase in estrogen levels and fluid buildup in the abdominal cavity, leading to OHSS.

Fertility Drugs and Ovarian Hyperstimulation Syndrome: What You Should Know
Symptoms of OHSS usually appear within a week after taking fertility drugs and can range from mild to severe. Mild symptoms include abdominal bloating, nausea, and breast tenderness, while severe symptoms can include severe abdominal pain, difficulty breathing, and decreased urine output.
It is essential to note that OHSS is a rare complication, and most women who take fertility drugs do not experience it. However, it is crucial to be aware of the symptoms and seek medical attention if they occur.
Managing and Preventing OHSS
If you experience any symptoms of OHSS, it is crucial to contact your doctor immediately. Your doctor may recommend stopping the fertility drugs and monitoring your condition closely. In mild cases, OHSS can be managed with rest, hydration, and pain relief medication.
In severe cases, hospitalization may be necessary to monitor your condition and provide supportive care, such as intravenous fluids and medication to reduce the risk of blood clots.
To prevent OHSS, your doctor will carefully monitor your response to fertility drugs through blood tests and ultrasound monitoring. The use of lower doses of fertility drugs or delaying treatment can also help reduce the risk of OHSS.
In rare cases, if OHSS does not improve with supportive care, your doctor may have to drain the excess fluid from your abdominal cavity through a procedure called paracentesis.
Conclusion
Fertility drugs can be a helpful tool for women struggling with infertility, but they also come with potential risks, such as OHSS. It is essential to be aware of the symptoms and seek medical attention if they occur. Your doctor will carefully monitor your response to fertility drugs to prevent and manage OHSS. Remember to discuss any concerns or questions you have with your doctor before starting any fertility treatment.
In summary, fertility drugs are medications used to stimulate the ovaries to produce more eggs and increase the chances of pregnancy. However, they can also increase the risk of Ovarian Hyperstimulation Syndrome (OHSS), a rare but potentially severe complication. It is crucial to be aware of the symptoms and seek medical attention if they occur. Your doctor will carefully monitor your response to fertility drugs to prevent and manage OHSS.